Objective To improve the recognition of treatment of adult T lymphoblastic lymphoma (TLL) with Hyper-CVAD regime. Methods The turnovers of 7 cases treated with Hyper-CVAD regime were summarized. Results Among the 7 cases, 1 case died after the first unfinished chemotherapy, 1 case gained complete remission before autologous stem cell transplantation but relapsed after transplantation, 3 cases gained complete remission until now, 2 cases without transplantation relapsed and then gave up following treatments after treating with ICE regime or the virgin regime, but the therapeutic effects were poor. Conclusions Adult TLL should get early chemotherapy treatments, and some special characteristics should be noted, the treatment does not relate to the stage, the chemotherapy treatment should be carried out regularly and enough, radiation of mediastinum mass can be applied after 4 cycles of Hyper-CVAD regime, choose suitable transplantation method.