单位：[1]Changhai Hospital, Second Military Medical University, Shanghai 200003, China[2]Institute of Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China[3]National Key Laboratory of Medical Immunology and Department of Immunology, Second Military Medical University, Shanghai 200433, China[4]The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.科研平台生物医学研究中心生物医学中心华中科技大学同济医学院附属同济医院
Sinomenine (SIN) is a purified alkaloid from the Chinese herb Sinomenium acutum. Previous studies demonstrated that SIN possesses anti-inflammatory and anti-apoptotic properties. We thus in the present report conducted studies to examine its impact on ischemia reperfusion (IR) induced renal injury. Precondition of mice with 200 mg/ kg of SIN provided significant protection for mice against IR-induced renal injury as manifested by the attenuated serum creatinine (Cre) and blood urea nitrogen (BUN) along with less severity for histological changes and tubular cell apoptosis. In line with these results, treatment of mice with SIN suppressed IR-induced inflammatory infiltration and the expression of chemokine CXCL-10, adhesion molecule ICAM-1, and cytokines TNF-a/IL-6. Mechanistic studies revealed that SIN inhibits NF-kappa B transcriptional activity to suppress IR-induced inflammatory response in the kidney, while it attenuates MAP kinase signaling to prevent tubular cells undergoing apoptosis after IR insult. Altogether, our data support that SIN could be a useful therapeutic agent for prevention and treatment of IR-induced renal injury in the clinical settings.
基金：
This work was supported by grants from the National Key Basic Research Program of China (2009CB522402) and the National Natural Science Foundation of China (31270957, 81001326).
第一作者单位：[1]Changhai Hospital, Second Military Medical University, Shanghai 200003, China
共同第一作者：
通讯作者：
通讯机构：[2]Institute of Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China[3]National Key Laboratory of Medical Immunology and Department of Immunology, Second Military Medical University, Shanghai 200433, China[*1]National Key Laboratory of Medical Immunology and Department of Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai 200433, China.[*2]Institute of Organ Transplantation, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
推荐引用方式(GB/T 7714)：
Zhao Zhiqing,Guan Rui,Song Shaohua,et al.Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2013,6(9):1702-1712.
APA：
Zhao, Zhiqing,Guan, Rui,Song, Shaohua,Zhang, Mingjian,Liu, Fang...&Wang, Quanxing.(2013).Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,6,(9)
MLA：
Zhao, Zhiqing,et al."Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 6..9(2013):1702-1712
