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Bipolarins A–H, eight new ophiobolin-type sesterterpenes with antimicrobial activity from fungus Bipolaris sp. TJ403-B1

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收录情况： ◇ SCIE ◇ CSCD-C

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单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

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关键词： Antimicrobial activity Bipolaris sp Ophiobolins Sesterterpenes

摘要：

Bipolarins A–H (1–8), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and 13C NMR calculations. Additionally, compound 5 exhibited significant selective antimicrobial activity against Enterococcus faecalis with an MIC value 8 μg·mL−1. © 2019 China Pharmaceutical University

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出版当年[2018]版：

大类 | 4 区医学

小类 | 3 区全科医学与补充医学 4 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区全科医学与补充医学 2 区药学

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出版当年[2017]版：

Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Q3 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY

影响因子： 4 最新[2023版] 3.7 最新五年平均 1.991 出版当年[2017版] 1.791 出版当年五年平均 1.667 出版前一年[2016版] 1.773 出版后一年[2018版]

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第一作者单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

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