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Nitric oxide inhibits ghrelin-induced cell proliferation and ERK1/2 activation in GH3 cells

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单位： [1]China Three Gorges Univ, Dept Neurosurg, Coll Clin Med Sci 1, Yichang Ctr Peoples Hosp, Yichang 443003, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol,Dept Neurosurg,Tongji Hosp,Tongji Med Coll,Wuhan 430030,Peoples R China

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关键词： Nitric oxide Ghrelin Cell proliferation Extracellular signal-regulated kinase

摘要：

Ghrelin stimulates growth hormone release and cell proliferation, which strongly supports a significant role for this peptide in the control of growth hormone-releasing adenomas function and growth. Nitric oxide can influence the stimulatory effects of ghrelin on growth hormone secretion in growth hormone-releasing adenomas. However, the effect of nitric oxide (NO) on ghrelin-induced cell proliferation and the mechanism of this effect in the adenoma were not clarified. In this study, we observed that ghrelin, at a concentration of 10(-9) to 10(-6) M, significantly increased BrdU incorporation into rat GH3 cells. A NO donor, S-nitroso-N-acetylpenicillamine (SNAP), blunted basal, and ghrelin-induced cell proliferation. A blocker of NO synthase, Nw-nitro-l-arginine methyl ester hydrochloride (NAME), had no influence on these actions. The activation of extracellular signal-regulated kinase (ERK) 1/2 was examined by western blotting. The results showed that SNAP reduced ghrelin-stimulated ERK1/2 activation but NAME had no influence on this activation. Together, this study indicates that NO inhibited ghrelin-induced cell proliferation by blocking ERK1/2 activation in GH3 cells.

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出版当年[2009]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

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出版当年[2008]版：

Q4 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 3 最新[2023版] 3.1 最新五年平均 1.842 出版当年[2008版] 2.082 出版当年五年平均 2.57 出版前一年[2007版] 1.278 出版后一年[2009版]

第一作者：

第一作者单位： [1]China Three Gorges Univ, Dept Neurosurg, Coll Clin Med Sci 1, Yichang Ctr Peoples Hosp, Yichang 443003, Hubei, Peoples R China

通讯作者：

通讯机构： [1]China Three Gorges Univ, Dept Neurosurg, Coll Clin Med Sci 1, Yichang Ctr Peoples Hosp, Yichang 443003, Hubei, Peoples R China [*1]China Three Gorges Univ, Dept Neurosurg, Coll Clin Med Sci 1, Yichang Ctr Peoples Hosp, Yi Ling Da Dao 183, Yichang 443003, Hubei, Peoples R China

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