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Rho-Associated Kinase Inhibitors Promote Microglial Uptake Via the ERK Signaling Pathway

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

作者：

单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, China

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关键词： Microglia Rho-associated kinase Uptake activity Extracellular-signal-regulated kinase

摘要：

Microglia are immunocompetent cells in the central nervous system that take up tissue debris and pathogens. Rho-associated kinase (ROCK) has been identified as an important regulator of uptake, proliferation, secretion, and differentiation in a number of cell types. Although ROCK plays critical roles in the microglial secretion of inflammatory factors, migration, and morphology, its effects on microglial uptake activity have not been well characterized. In the present study, we found that treatment of BV2 microglia and primary microglia with the ROCK inhibitors Y27632 and fasudil increased uptake activity and was associated with morphological changes. Furthermore, western blots showed that this increase in uptake activity was mediated through the extracellular-signal-regulated kinase (ERK) signaling cascade, indicating the importance of ROCK in regulating microglial uptake activity.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区神经科学

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出版当年[2014]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.9 最新[2023版] 5.4 最新五年平均 2.509 出版当年[2014版] 2.134 出版当年五年平均 1.832 出版前一年[2013版] 2.322 出版后一年[2015版]

第一作者：

第一作者单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

通讯作者：

通讯机构： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

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