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CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice

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收录情况： ◇ SCIE

作者：
Zhang, Hui[1] * ; Gong, Quan[1,2] ; Li, Jun-hua[3] ; Kong, Xiao-ling[1] ; Tian, Li[1] ; Duan, Li-hua[1] ; Tong, Jing[1] ; Song, Fei-fei[1] ; Fang, Min[1] ; Zheng, Fang[1] ; Xiong, Ping[1] ; Tan, Zheng[1] ; Gong, Fei-li[1] ;
单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China [2]Yangtze Univ, Sch Med, Dept Immunol, Jinzhou 434023, Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Organ Transplantat,Wuhan 430030,Peoples R China
出处：
DOI： 10.1016/j.intimp.2009.09.025
ISSN：

关键词： Concanavalin A CpG ODN TNF-alpha IFN-gamma NF-kappa B

摘要：
T cell-mediated hepatic damage plays a key role in the pathogenesis of liver diseases Such as autoimmune hepatitis, viral hepatitis and acute liver failure CpG-containing oligodeoxynucleotides (CpG ODN), a ligand for toll-like receptor (TLR) 9. is widely used as ail immunological adjuvant In the present study. we investigated the effect of CpG ODN on T cell-mediated liver injury in a murine model of concanavalin A (Con A)-induced hepatitis We found that the aminotransferase level was significantly decreased in CpG ODN pretreated mice and the Survival of the mice was markedly prolonged. CpG ODN pretreatment inhibited NF-kappa B DNA binding activity As a result, the systemic/liver levels of TNF-alpha and IFN-gamma were significantly suppressed Furthermore. the activation of inflammatory cells was diminished by CpG ODN pretreatment These results Suggest that CpG ODN pretreatment protects the mice from Con A-induced liver injury via inhibiting hepatocyte apoptosis, inflammation and activation of lymphocytes (C) 2009 Elsevier B V All rights reserved

基金：
National Development Program [2007CB512400]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类 | 3 区 医学
小类 | 4 区 免疫学 4 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
JCR分区：
出版当年[2008]版：
Q3 PHARMACOLOGY & PHARMACY Q3 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Hui,Gong Quan,Li Jun-hua,et al.CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2010,10(1):79-85.doi:10.1016/j.intimp.2009.09.025.
APA：
Zhang, Hui,Gong, Quan,Li, Jun-hua,Kong, Xiao-ling,Tian, Li...&Gong, Fei-li.(2010).CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice.INTERNATIONAL IMMUNOPHARMACOLOGY,10,(1)
MLA：
Zhang, Hui,et al."CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice".INTERNATIONAL IMMUNOPHARMACOLOGY 10..1(2010):79-85

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