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Change Profiles in Matrix Metalloproteinase-2 and-9 in Induced Endometriosis in Mice

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单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Gynecol & Obstet,Wuhan 430022,Peoples R China [2]Xiamen Med Univ, Affiliated Hosp 1, Dept Gynecol & Obstet, Xiamen 361004, Peoples R China

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关键词： matrix metalloproteinase endometriosis animal model

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To examine the changes in matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in the development and progression of endometriosis, real time quantitative polymerase chain reaction, enzyme-linked immunoabsorbent assay and gelatin zymography were employed to determine the mRNA and protein levels and activities of MMP-2 and MMP-9 from the first day to the 21(st) day after the induction in mice with induced endometriosis (experimental group) and sham-operated animals (controls). The results showed that the mRNA and protein levels and activities of the MMP-2 and MMP-9 were significantly increased on the first day after the induction and the level of MMP-2 stayed at a level higher than that in the control group. MMP-9 had two or three peaks during the 21 days, taking place at day 1, 4 and 15. It is concluded that the changes in the MMP-2 and MMP-9 might be involved in pathogenesis of endometriosis.

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影响因子： 0 最新[2023版] 0 最新五年平均 0 出版当年[2008版] 0 出版当年五年平均 0 出版前一年[2007版] 0.311 出版后一年[2009版]

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第一作者单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Gynecol & Obstet,Wuhan 430022,Peoples R China [2]Xiamen Med Univ, Affiliated Hosp 1, Dept Gynecol & Obstet, Xiamen 361004, Peoples R China

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