Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases
Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-inducing cysteine-rich protein with Kazal motifs), a novel membrane-anchored inhibitor of MMPs, could regulate the expressions of MMP-2, 9 and MT1-MMP as a cell surface-signaling molecule. Thus, we propose that RECK may play an important role in regulating MMPs in the ECM degradation of periodontal diseases. The RECK/MMPs signaling pathway could provide a new approach for prevention and treatment of RECK in periodontal diseases by blocking MMPs.
基金：
National Natural Science Foundation of China [81300883, 81171460]; Wuhan Innovative Talent Development Funds
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Nian,Zhou Bin,Zhu Guangxun.Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases[J].MEDICAL SCIENCE MONITOR.2016,22:1936-1938.doi:10.12659/MSM.896546.
APA：
Liu, Nian,Zhou, Bin&Zhu, Guangxun.(2016).Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases.MEDICAL SCIENCE MONITOR,22,
MLA：
Liu, Nian,et al."Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases".MEDICAL SCIENCE MONITOR 22.(2016):1936-1938
