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Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice

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收录情况： ◇ SCIE

作者：
Chen, Guangzhi[1,2] * ; Wang, Peihua[1,2] ; Zhao, Gang[1,2] ; Xu, Gang[1,2] ; Gruzdev, Artiom[3] ; Zeldin, Darryl C.[3] ; Wang, Dao Wen[1,2,*1] ;
单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Gene Therapy Ctr, Wuhan 430030, Peoples R China [3]NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA
出处：
DOI： 10.1016/j.prostaglandins.2011.06.009
ISSN：

关键词： Arachidonic acids Cytochrome P450 epoxygenase Streptozotocin Diabetic nephropathy Tubular epithelial-inesenchymal transdifferentiation

摘要：
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs). which play important and diverse roles in the cardiovascular system. The anti-inflammatory, antiapoptotic, pro-angiogenic, and anti-hypertensive properties of EETs in the cardiovascular system suggest a beneficial role for EETs in diabetic nephropathy. This study investigated the effects of endothelial specific overexpression of CYP2J2 epoxygenase on diabetic nephropathy in streptozotocin-induced diabetic mice. Endothelial CYP2J2 overexpression attenuated renal damage as measured by urinary microalbumin and glomerulosclerosis. These effects were associated with inhibition of TGF-beta/Smad signaling in the kidney. Indeed, overexpression of CYP2J2 prevented TGF-beta 1-induced renal tubular epithelial-mesenchymal transition in vitro. These findings highlight the beneficial roles of the CYP epoxygenase-EET system in the pathogenesis of diabetic nephropathy. (C) 2011 Elsevier Inc. All rights reserved.

基金：
National Education Ministration project; Nature Science Foundation Committee [30930039, 30700377]; Wuhan City grant
语种：
外文
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中科院(CAS)分区：
出版当年[2010]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
JCR分区：
出版当年[2009]版：
Q3 CELL BIOLOGY Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Gene Therapy Ctr, Wuhan 430030, Peoples R China
通讯作者：
通讯机构： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Gene Therapy Ctr, Wuhan 430030, Peoples R China [*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, 1095 Jiefang Ave, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Guangzhi,Wang Peihua,Zhao Gang,et al.Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice[J].PROSTAGLANDINS & OTHER LIPID MEDIATORS.2011,96(1-4):63-71.doi:10.1016/j.prostaglandins.2011.06.009.
APA：
Chen, Guangzhi,Wang, Peihua,Zhao, Gang,Xu, Gang,Gruzdev, Artiom...&Wang, Dao Wen.(2011).Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.PROSTAGLANDINS & OTHER LIPID MEDIATORS,96,(1-4)
MLA：
Chen, Guangzhi,et al."Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice".PROSTAGLANDINS & OTHER LIPID MEDIATORS 96..1-4(2011):63-71

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