单位：[1]Division of Cardiology,Department of Internal Medicine and Gene Therapy Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院大内科内科学系心血管内科内科门诊[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Huazhong University of Science and Technology,Hubei Province,Wuhan,China华中科技大学同济医学院附属同济医院内科学系心血管内科[3]Department of Rheumatology and Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei,Wuhan,China内科学系风湿免疫内科[4]Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany风湿免疫内科内科学系
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs). Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases (CVD), cancers, and inflammatory diseases. This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2. Thus, we herein present a synopsis of AA metabolism in human health, cardiovascular and cancer biology, and the signaling pathways involved in these processes. To explore the role of the AA metabolism and potential therapies, we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions.
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81790624, 81700333, 81900363, 81900244]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB 1039/A6]
第一作者单位：[1]Division of Cardiology,Department of Internal Medicine and Gene Therapy Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Huazhong University of Science and Technology,Hubei Province,Wuhan,China[3]Department of Rheumatology and Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei,Wuhan,China
共同第一作者：
通讯作者：
通讯机构：[1]Division of Cardiology,Department of Internal Medicine and Gene Therapy Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Huazhong University of Science and Technology,Hubei Province,Wuhan,China
推荐引用方式(GB/T 7714)：
wang bei,wu lujin,chen jing,et al.Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets[J].SIGNAL TRANSDUCTION AND TARGETED THERAPY.2021,6(1):doi:10.1038/s41392-020-00443-w.
APA：
wang,bei,wu,lujin,chen,jing,dong,lingli,chen,chen...&wang,dao wen.(2021).Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6,(1)
MLA：
wang,bei,et al."Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6..1(2021)
医学