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Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang, Z. -H.[1,5] * ; Li, L.[1] ; Zhao, X. -P.[1] ; Glebe, D.[2] ; Bremer, C. M.[2] ; Zhang, Z. -M.[1] ; Tian, Y. -J.[1] ; Wang, B. -J.[1] ; Yang, Y.[1] ; Gerlich, W.[2] ; Roggendorf, M.[3] ; Li, X.[5] ; Mengji Lu[3,4] ; Dongliang Yang[1] ;
单位： [1]Division of Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Medical Virology, Justus-Liebig University of Giessen, Giessen, Germany [3]Institute of Virology, Universita¨tsklinikum Essen, Essen, Germany [4]Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [5]Department of Infectious Diseases, the First Affiliated Hospital, Anhui Medical University, Hefei, China
出处：
DOI： 10.1111/j.1365-2893.2010.01322.x
ISSN：

关键词： hepatitis B surface antigen hepatitis B virus persistent HBV infection seroconversion surface antibody

摘要：
Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsies confirmed the expression of HBV proteins in the liver of one patient. The neutralizing ability of anti-HBs in patient sera was demonstrated by blocking HBV infection of primary tupaia hepatocytes. Analysis of the HBsAg-encoding region of HBV isolates from patients indicated the coexistence of heterogeneous HBV genomes in patients. The majority of recombinant variant HBsAg was reactive in HBsAg assays and was able to bind to anti-HBs. Circulating immune complexes (CIC) of HBsAg in patient sera could be detected by polyethylene glycol precipitation and trypsin digestion. Thus, neutralizing anti-HBs may appear in chronic HBV carriers for long periods but does not necessarily lead to complete viral clearance.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30571646]; National High Technology Research and Development Programme of ChinaNational High Technology Research and Development Program of China [2006AA02Z128]; National Key Basic Research Programme of ChinaNational Basic Research Program of China [2005CB522901, 2007CB512804]; Specialized Research Fund for the Doctoral Programme of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20093420120005]

基金编号： 30571646 2006AA02Z128 2005CB522901 2007CB512804 20093420120005

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类 | 3 区 医学
小类 | 2 区 传染病学 3 区 胃肠肝病学 3 区 病毒学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 病毒学 4 区 胃肠肝病学
JCR分区：
出版当年[2009]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY Q1 INFECTIOUS DISEASES Q2 VIROLOGY
最新[2023]版：
Q3 GASTROENTEROLOGY & HEPATOLOGY Q3 INFECTIOUS DISEASES Q3 VIROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者：
第一作者单位： [1]Division of Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [5]Department of Infectious Diseases, the First Affiliated Hospital, Anhui Medical University, Hefei, China
通讯作者：
通讯机构： [*1]Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany [*2]Division of Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
推荐引用方式(GB/T 7714)：
Zhang Z. -H.,Li L.,Zhao X. -P.,et al.Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance[J].JOURNAL OF VIRAL HEPATITIS.2011,18(6):424-433.doi:10.1111/j.1365-2893.2010.01322.x.
APA：
Zhang, Z. -H.,Li, L.,Zhao, X. -P.,Glebe, D.,Bremer, C. M....&Dongliang Yang.(2011).Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance.JOURNAL OF VIRAL HEPATITIS,18,(6)
MLA：
Zhang, Z. -H.,et al."Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance".JOURNAL OF VIRAL HEPATITIS 18..6(2011):424-433

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