Resveratrol (trans-3, 4', 5-trihydroxystilbene) is a natural phytoalexin found in grapes and other plants that has anti-cancer and anti-inflammatory effects. The aim of this study was to find that resveratrol suppresses matrix metalloproteinase-2(MMP-2) expression in hepatoma in vivo. Tumor volume and invasion ability of liver transplanted tumor in nude mice were observed. MMP-2 mRNA and protein of the tumor were investigated by RT-PCR and Western-blot. NF-kappa B activity was measured by EMSA. Growth of the transplanted tumor was obviously by resveratrol at 50 mg kg(-1) (p < 0.05) and 100 mg kg(-1) (p < 0.05). Liver metastasis of the tumor was inhibited by 100 mg kg(-1) resveratrol (p < 0.05). MMP-2 protein was down regulated due to decrease MMP-2 mRNA expression. NF-kappa B activity was also extensively inhibited by resveratrol at 50 and 100 mg kg(-1). The results suggest that resveratrol may inhibit growth and invasion ability by down regulated MMP-2 expression of hepatoma in nude mice. This effect was regulated by NF-kappa B Pathway.
第一作者单位：[1]Henan Prov Peoples Hosp, Dept Hepatobiliary Surg, Zhengzhou, Peoples R China[2]Huazhong Univ Sci & Technol,Dept Hepatobiliary Surg,TongJi Med Coll,TongJi Hosp,Wuhan 430074,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Deyu,Chen Xiaoping,Yu Haibo.Resveratrol Inhibits MMP-2 Expression of Hepatoma in Nude Mice[J].JOURNAL OF ANIMAL AND VETERINARY ADVANCES.2011,10(1):33-37.
APA：
Li, Deyu,Chen, Xiaoping&Yu, Haibo.(2011).Resveratrol Inhibits MMP-2 Expression of Hepatoma in Nude Mice.JOURNAL OF ANIMAL AND VETERINARY ADVANCES,10,(1)
MLA：
Li, Deyu,et al."Resveratrol Inhibits MMP-2 Expression of Hepatoma in Nude Mice".JOURNAL OF ANIMAL AND VETERINARY ADVANCES 10..1(2011):33-37
