Purpose of work Our study provides a promising alternative of biomimetic coating which functionalizes the dental implant with adhesion peptides and may be useful for enhancing the bone remodeling around Ti implants. A chimeric peptide consisting of an Arg-Gly-Asp (RGD) sequence (mediating cell adhesion) and a RKLPDA (minTBP-1) sequence (specifically recognizing and binding to Ti substrate) was designed and synthesized. The chimeric peptide affinity to Ti disks, as well as its role in mediating MC3T3-E1 cell attachment and afterwards spreading on pre-coated Ti disks, was investigated. The chimeric peptide not only showed favorable affinity to Ti surfaces but also facilitated the adhesion of MC3T3-E1 cells.
基金：
National Science Foundation of China (NSFC) [30700957]
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China[*1]Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, 1095 Jiefang Rd, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Dan,Mao Jing,Zhou Bin,et al.A chimeric peptide that binds to titanium and mediates MC3T3-E1 cell adhesion[J].BIOTECHNOLOGY LETTERS.2011,33(1):191-197.doi:10.1007/s10529-010-0411-9.
APA：
Wang, Dan,Mao, Jing,Zhou, Bin,Liao, Xiao-Fu,Gong, Shi-Qiang...&Zhang, Jing-Tao.(2011).A chimeric peptide that binds to titanium and mediates MC3T3-E1 cell adhesion.BIOTECHNOLOGY LETTERS,33,(1)
MLA：
Wang, Dan,et al."A chimeric peptide that binds to titanium and mediates MC3T3-E1 cell adhesion".BIOTECHNOLOGY LETTERS 33..1(2011):191-197
