详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Increased expression of cell adhesion molecules in myofasciitis

77| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Neurology, Air Force Medical University Tangdu Hospital, Xi’an, China [2]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

出处：

DOI：

ISSN：

关键词： myofasciitis dysregulated immune response cell adhesion molecules endothelial activation myopathy

摘要：

BackgroundMyofasciitis is a heterogeneous group of diseases pathologically characterized by inflammatory cell infiltration into the fascia. Endothelial activation plays a critical role in the pathogenesis of the inflammatory response. However, the expression of cellular adhesion molecules (CAMs) in myofasciitis has not been investigated. MethodsData on clinical features, thigh magnetic resonance imaging, and muscle pathology were collected from five patients with myofasciitis. Immunohistochemical (IHC) staining and Western blot (WB) of the muscle biopsies from patients and healthy controls were performed. ResultsIncreased levels of serum pro-inflammatory cytokines, including IL-6, TNF-alpha, and IL-2R, were detected in four patients. IHC staining and WB indicated significantly increased expression of cell adhesion molecules in blood vessels or inflammatory cells within the perimysium in muscle and fascia tissues of patients with myofasciitis compared to controls. ConclusionThe up-regulation of CAMs in myofasciitis indicates endothelial activation, which may be potential therapy targets for the treatment of myofasciitis.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区神经科学 3 区临床神经病学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2021]版：

Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 4.086 出版当年[2021版] 4.321 出版当年五年平均 4.003 出版前一年[2020版] 3.4 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Neurology, Air Force Medical University Tangdu Hospital, Xi’an, China [2]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis [2]The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019. [3]Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway [4]TNF-alpha induces endothelial dysfunction via PKC-zeta-dependent NADPH oxidase activation [5]CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells [6]Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis [7]Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection [8]Severe Recurrent Necrotizing Myopathy in Pregnancy: A Case Report [9]Immunotherapy reversed myopathy but not cardiomyopathy in a necrotizing autoimmune myopathy patient with positive anti-SRP and MDA-5 autoantibodies [10]CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation