RY10-4, a novel protoapigenone analog, shows potent cytotoxicity against a broad spectrum of human cancer cells. Here we investigate its anti-tumor activity on breast cancer. The results indicated that RY10-4 suppressed proliferation, arrested cell cycle, induced apoptosis and inhibited invasion in MDA-MB-231, MCF-7 and SKBR3 breast cancer cells. Western blot analysis showed that RY10-4 down-regulated the PI3K/Akt signaling pathway and inhibited doxorubicin-induced p-Akt. Moreover, it effectively suppressed tumor growth in mice without major side effects. Therefore. RY10-4 had potential anti-tumor activity, and could be used as a lead to design more potent derivatives. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
基金：
National Nature Science Foundation of China [81173093]; Nature Science Foundation of Hubei Province [2009CDA067]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Key Lab Nat Med Chem & Resources Evaluat Hubei Pr, Wuhan 430030, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Mol Med Ctr, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Yuan Qianying,Cai Shaoxin,Zhang Xuenong,et al.A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer[J].CANCER LETTERS.2012,324(2):210-220.doi:10.1016/j.canlet.2012.05.025.
APA：
Yuan, Qianying,Cai, Shaoxin,Zhang, Xuenong,Liu, Ziwei,Li, Zhaoming...&Ruan, Jinlan.(2012).A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer.CANCER LETTERS,324,(2)
MLA：
Yuan, Qianying,et al."A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer".CANCER LETTERS 324..2(2012):210-220
医学