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TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol,Inst Pathol,Tongji Hosp,Tongji Med Coll,Wuhan 430030,Peoples R China

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关键词： lipoma preferred partner smooth muscle progenitor cells differentiation migration Rho kinase

摘要：

Lipoma preferred partner (LPP) has been identified as a protein which is highly selective for smooth muscle progenitor cells (SMPCs) and regulates differentiation and migration of SMPCs, but mechanisms of LPP expression are not elucidated clearly. The aim of the present study was to discuss the mechanisms by which LPP expression is regulated in the differentiation and migration of SMPCs induced by TGF-beta 1. It was found that TGF-beta 1 could significantly increase the expression of LPP, smooth muscle alpha-actin, smooth muscle myosin heavy chain (SM-MHC), and smoothelin in SMPCs. Moreover, inactivation of Rho kinase (ROK) with ROK inhibitors significantly inhibited LPP mRNA expression in TGF-beta 1-treated SMPCs and mouse aortic smooth muscle cells (MAoSMCs). At the same time, LPP silencing with short interfering RNA significantly decreased SMPCs migration. In conclusion, LPP appears to be a ROK-dependant SMPCs differentiation marker that plays a role in regulating SMPCs migration.

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出版当年[2011]版：

大类 | 4 区医学

小类 | 4 区生化与分子生物学

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无

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出版当年[2010]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 0.405 出版当年[2010版] 0 出版当年五年平均 0.311 出版前一年[2009版] 0.385 出版后一年[2011版]

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第一作者单位： [1]Huazhong Univ Sci & Technol,Inst Pathol,Tongji Hosp,Tongji Med Coll,Wuhan 430030,Peoples R China

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