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Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

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收录情况： ◇ SCIE

作者：
Chen, Jinglou[1] * ; Lei, Yongfang[1] ; Wu, Guanghua[1] ; Zhang, Yonghui[1,*1] ; Fu, Wei[2] ; Xiong, Chaomei[1] ; Ruan, Jinlan[1] ;
单位： [1]Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, Wuhan 430030, Hubei Province, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430030, Hubei Province, Peoples R China
出处：
DOI： 10.1016/j.jep.2011.11.002
ISSN：

关键词： Macrothelypteris torresiana Nephrotic syndrome Oxidative stress Vascular endothelial growth factor Nitric oxide

摘要：
Ethnopharmacological relevance: Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness. Aim of the study:The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT). Materials and methods: The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice. Results: In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway. Conclusions: It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

基金：
State Natural Sciences Fund [NO30973864]; Ministry of Education [NO20090142110021]; Key Natural Science Fund of Hubei Province [NO2009CDA067]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类 | 3 区 医学
小类 | 2 区 全科医学与补充医学 3 区 药物化学 3 区 药学 3 区 植物科学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 全科医学与补充医学 1 区 药学 2 区 药物化学 2 区 植物科学
JCR分区：
出版当年[2010]版：
Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PLANT SCIENCES Q2 PHARMACOLOGY & PHARMACY Q2 CHEMISTRY, MEDICINAL
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, Wuhan 430030, Hubei Province, Peoples R China
通讯作者：
通讯机构： [1]Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, Wuhan 430030, Hubei Province, Peoples R China [*1]Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, 13 Hangkong Rd, Wuhan 430030, Hubei Province, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Jinglou,Lei Yongfang,Wu Guanghua,et al.Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines[J].JOURNAL OF ETHNOPHARMACOLOGY.2012,139(1):207-213.doi:10.1016/j.jep.2011.11.002.
APA：
Chen, Jinglou,Lei, Yongfang,Wu, Guanghua,Zhang, Yonghui,Fu, Wei...&Ruan, Jinlan.(2012).Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines.JOURNAL OF ETHNOPHARMACOLOGY,139,(1)
MLA：
Chen, Jinglou,et al."Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines".JOURNAL OF ETHNOPHARMACOLOGY 139..1(2012):207-213

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