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Loss of downregulated in adenoma (DRA) impairs mucosal HCO3-secretion in murine ileocolonic inflammation

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收录情况： ◇ SCIE

作者：

单位： [1]Hannover Med Sch, Dept Gastroenterol, D-30625 Hannover, Germany [2]Hannover Med Sch, Inst Lab Anim Sci, D-30625 Hannover, Germany [3]Univ Illinois, Dept Med, Champaign, IL 61820 USA [4]Huazhong Univ Sci & Technol, Dept Gastroenterol, Tongji Hosp, Wuhan 430074, Hubei, Peoples R China [5]Huazhong Univ Sci & Technol, Dept Nephrol, Tongji Hosp, Wuhan 430074, Hubei, Peoples R China [6]Capital Med Univ, Dept Physiol, Beijing, Peoples R China

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关键词： inflammatory bowel disease bicarbonate anion exchanger colon

摘要：

Background: Ileocolonic luminal pH has been reported to be abnormally low in inflammatory bowel disease (IBD) patients, and one of the causative factors may be reduced epithelial HCO?3- secretory rate (J?HCO3?-). Disturbances in J?HCO3?- may occur due to inflammation-induced changes in the crypt and villous architecture, or due to the effect of proinflammatory cytokines on epithelial ion transporters.

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出版当年[2011]版：

大类 | 2 区医学

小类 | 2 区胃肠肝病学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区胃肠肝病学

JCR分区：

出版当年[2010]版：

Q1 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 4.5 最新[2023版] 4.7 最新五年平均 4.613 出版当年[2010版] 4.855 出版当年五年平均 4.643 出版前一年[2009版] 4.855 出版后一年[2011版]

第一作者：

第一作者单位： [1]Hannover Med Sch, Dept Gastroenterol, D-30625 Hannover, Germany [4]Huazhong Univ Sci & Technol, Dept Gastroenterol, Tongji Hosp, Wuhan 430074, Hubei, Peoples R China

通讯作者：

通讯机构： [1]Hannover Med Sch, Dept Gastroenterol, D-30625 Hannover, Germany [*1]Hannover Med Sch, Dept Gastroenterol, Carl Neuberg Str 1, D-30625 Hannover, Germany

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