Nine germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety, scapiformolactones A-I (1-9), and one known seco-germacrane sesquiterpenoid, 3,7,11-trimethyldodeca-1,6,9-triene-3,11-diol (10), were isolated from whole plants of Salvia scapiformis Hance. Their structures were elucidated by spectroscopic methods including HR-ESIMS, IR, UV, NMR, and CD, as well as by quantum mechanical calculations and chemical transformations. Structures of compounds 1-3 were also confirmed by single-crystal X-ray diffraction analysis. Six germacrane 6,15-diol derivatives (11-16) were obtained by chemical transformation. Compounds 1-9 and 11-16 were evaluated for their in vitro immunomodulatory effects on T and B cells, as well as their in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2013 Elsevier Ltd. All rights reserved.
基金：
Hubei Key Laboratory Foundation of Natural Medicinal Chemistry and Resource Evaluation; Huazhong University of Science and Technology [2010-3]; Fundamental Research Funds for the Central Universities [HUST: 2012QN003]; Scientific Research Foundation for the Returned Oversea Chinese Scholars; State Education Ministry of China [2010-1561, 40th, NCET-2008-0224]; Program for New Century Excellent Talents in University
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Lai Yongji,Xue Yongbo,Zhang Mengke,et al.Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from Salvia scapiformis[J].PHYTOCHEMISTRY.2013,96:378-388.doi:10.1016/j.phytochem.2013.10.003.
APA：
Lai, Yongji,Xue, Yongbo,Zhang, Mengke,Zhang, Jinwen,Tang, Wei...&Zhang, Yonghui.(2013).Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from Salvia scapiformis.PHYTOCHEMISTRY,96,
MLA：
Lai, Yongji,et al."Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from Salvia scapiformis".PHYTOCHEMISTRY 96.(2013):378-388
