单位：[1]Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030华中科技大学同济医学院附属同济医院肿瘤生物医学中心[2]Radiotherapy and Chemotherapy Department, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430000[3]Department of Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China华中科技大学同济医学院附属协和医院[4]Department of Gynecologic Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Several lines of evidence support an important role for Snail, a transcriptional factor, in breast cancer. Overexpression of Snail has been associated with breast cancer metastasis, although the specific role of Snail in the process remains unclear. To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP-2, were reduced in the breast tumor cell lines MDA-MB-231 and MDA-MB-435S, and their biological responses were studied in vitro and in vivo. For the first time, it was observed that downregulated Snail expression is correlated with a significant inhibition of the expression and activity of RhoA GTPase, as well as MMP-2. The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. In conclusion, the present findings demonstrate a key regulatory role for Snail in breast tumor growth and progression.
基金：
National Nature and Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30700895, 30770913, 30500596, 30528012]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2009CB521808]; Nature and Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2011CBD542]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [HUST: 2012TS058]
第一作者单位：[1]Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030
共同第一作者：
通讯作者：
通讯机构：[1]Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030[*1]Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, Hubei 430030, P.R. China
推荐引用方式(GB/T 7714)：
zhang ali,wang quansheng,han zhiqiang,et al.Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase[J].ONCOLOGY LETTERS.2013,6(2):339-346.doi:10.3892/ol.2013.1385.
APA：
zhang,ali,wang,quansheng,han,zhiqiang,hu,wei,xi,ling...&ma,ding.(2013).Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase.ONCOLOGY LETTERS,6,(2)
MLA：
zhang,ali,et al."Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase".ONCOLOGY LETTERS 6..2(2013):339-346
