Streptococcus mutans (S. mutans) forms part of the commensal microflora and is deemed to be the major pathogen responsible for the generation of dental caries. The enzyme, sortase A enzyme, modulates the surface properties and cariogenicity of S. mutans. Curcumin has been reported to be an inhibitor of Staphylococcus aureus sortase A. In this study, inhibition of a purified S. mutans UA159 sortase A by curcumin was evaluated. Curcumin exerted strong inhibitory activity with a half maximal inhibitory concentration (IC50) of 10.2 +/- 0.7 mu M which was lower than the minimum inhibitory concentration of 175 mu M and the minimum bactericidal concentration of 350 mu M. These results indicated that curcumin is a S. mutans UA159 sortase A inhibitor and therefore represents as a promising anticaries agent.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Stomatol, Tongji Hosp, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Stomatol, Tongji Hosp, Wuhan 430030, Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Stomatol, Tongji Hosp, 1095 Jiefang Rd, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Hu Ping,Huang Ping,Chen Wei Min.Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159[J].APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY.2013,171(2):396-402.doi:10.1007/s12010-013-0378-9.
APA：
Hu, Ping,Huang, Ping&Chen, Wei Min.(2013).Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,171,(2)
MLA：
Hu, Ping,et al."Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159".APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 171..2(2013):396-402
