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Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms

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收录情况： ◇ SCIE

作者：
Wang Dan[1,2] * ; Yu Jian[2,3] * ; Liu He[2] ; Zhang Tian[4] ; Haney Evan F[5] ; Hancock Robert E W[5] ; Peng Lin[6] ; Shen Ya[2] ;
单位： [1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [2]Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada [3]State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China [4]School of Medicine, Vanderbilt University, Nashville, TN, United States [5]Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada [6]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China
出处：
DOI： 10.1016/j.jdent.2023.104777
ISSN：

关键词： Biofilm Corrosion Peptide Surface roughness Titanium

摘要：
To investigate the effectiveness of a d-enantiomeric antibiofilm peptide (DJK-5) on the anticorrosion ability of titanium (Ti) with different surface roughness against Streptococcus mutans biofilms.Commercially pure Ti disks with machined (MA, smooth) or sandblasted + acid-etched (SLA, rough) surfaces were prepared and characterized. All disks were divided into three groups: a positive control (PC) group with S. mutans, a DJK-5-treated group, and a negative control (NC) group without S. mutans. Biofilm formation and corrosion on Ti surfaces were determined by confocal laser scanning microscopy and scanning electron microscopy after 2 and 6 days, and the electrochemical properties were evaluated.Ten μg/mL of DJK-5 killed 83.3 % and 87.4 % of biofilms on SLA and MA Ti surfaces, respectively after 2 days, and 72.9 % and 77.7 % after 6 days, with more bacteria surviving on SLA surfaces with higher roughness (p < 0.05). DJK-5 treatment induced less surface defects with tiny pit corrosion than PC. DJK-5 treatment when compared to PC, led to electrochemical properties more reflecting NC surfaces, including significantly less negative corrosion potential, lower corrosion current, and higher passive film resistance (p < 0.05). SLA surfaces exhibited higher current density and lower resistance than MA surfaces (p < 0.05).DJK-5 effectively enhanced the corrosion resistance of Ti with different surface roughness while killing S. mutans biofilms, and smooth surfaces were more susceptible to peptide treatment.The antibiofilm peptide is promising for promoting the anticorrosion ability of Ti against biofilms, thereby preventing biofilm-related infections.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was supported by funding from the Canadian Institutes for Health Research (CIHR) FDN-154287 to R.E.W.H. (R.E.W.H. holds a UBC Killam Professorship), S. Wah Leung Endowment Fund (2023) of UBC Faculty of Dentistry, and Basic Research Project of Sichuan Provincial Department of Science and Technology (20YYJC3660). J. Yu’s research conducted at the UBC Faculty of Dentistry was supported by China Scholarship Council (202006275049).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 1 区 牙科与口腔外科
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 牙科与口腔外科
JCR分区：
出版当年[2021]版：
Q1 DENTISTRY, ORAL SURGERY & MEDICINE
最新[2023]版：
Q1 DENTISTRY, ORAL SURGERY & MEDICINE

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [2]Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Dan,Yu Jian,Liu He,et al.Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms[J].JOURNAL OF DENTISTRY.2023,139:doi:10.1016/j.jdent.2023.104777.
APA：
Wang Dan,Yu Jian,Liu He,Zhang Tian,Haney Evan F...&Shen Ya.(2023).Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms.JOURNAL OF DENTISTRY,139,
MLA：
Wang Dan,et al."Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms".JOURNAL OF DENTISTRY 139.(2023)

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