Di-(2-ethylhexyl)-Phthalate (DEHP) can affect glucose and insulin homeostasis in periphery and lead to insulin resistance, especially exposure of DEHP during critical developmental period. Given the potential relationship between insulin resistance and pathogenesis of Alzheimer's disease (AD) in elderly life, we investigated the relationship between perinatal DEHP exposure and AD pathogenesis. Our results suggested that perinatal exposure to DEHP can affect the expression of insulin and insulin-Akt- GSK-3 beta signal pathway in hippocampus. Furthermore, impaired cognitive ability and increased level of phospho-Tau was observed in DEHP-exposed rat offspring (1.25 +/- 0.11 vs. 0.47 +/- 0.07, P < 0.05). The present study demonstrates that perinatal exposure to DEHP may be a potential risk factor for AD pathogenesis associated with insulin resistance and insulin metabolism disorder in the hippocampus. (c) 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 596-603, 2014.
基金：
National Natural Science Foundation of China [30600485]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Gen Thorac Surg,Wuhan 430030,Hubei,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Wei,Ban Jin-Bao,Zhang Ni,et al.Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats[J].ENVIRONMENTAL TOXICOLOGY.2014,29(5):596-603.doi:10.1002/tox.21785.
APA：
Sun, Wei,Ban, Jin-Bao,Zhang, Ni,Zu, Yu-Kun&Sun, Wen-Xiao.(2014).Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats.ENVIRONMENTAL TOXICOLOGY,29,(5)
MLA：
Sun, Wei,et al."Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats".ENVIRONMENTAL TOXICOLOGY 29..5(2014):596-603
