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Alkali-Soluble Polysaccharide, Isolated from Lentinus edodes, Induces Apoptosis and G2/M Cell Cycle Arrest in H22 Cells Through Microtubule Depolymerization

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单位： [1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

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关键词： Lentinus edodes polysaccharide anti-tumour activity apoptosis cell cycle microtubules network

摘要：

The aim of the study was to evaluate the pro-apoptotic effects of polysaccharides derived from Lentinus edodes and further elucidated the mechanisms of this action. Our results demonstrated that marked morphological changes of apoptosis were observed after treatment of L.edodes polysaccharides [Lentinan (LTN)]. Moreover, LTN-induced cell apoptosis was characterized by a rapid stimulation of reactive oxygen species production, the loss of mitochondrial membrane potential and an increase in intracellular concentration of Ca2+. In addition, the results of the haematoxylin and eosin and TUNEL assay further confirmed that LTN-induced apoptosis in vivo. Furthermore, flow cytometry analysis showed that LTN could arrest the cell cycle at G2/M phase, and immunofluorescence showed LTN caused disruption of microtubule. These results suggest that disruption of cellular microtubule network, arrest of the cell cycle at G2/M phase and induction of apoptosis may be one of the possible mechanisms of anti-tumour effect of LTN. Copyright (c) 2014 John Wiley & Sons, Ltd.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区药物化学 4 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药物化学 2 区药学

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出版当年[2012]版：

Q3 PHARMACOLOGY & PHARMACY Q3 CHEMISTRY, MEDICINAL

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.1 最新[2023版] 7 最新五年平均 2.068 出版当年[2012版] 2.438 出版当年五年平均 2.086 出版前一年[2011版] 2.397 出版后一年[2013版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China

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通讯机构： [1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China [*1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, 1277 Jiefang Rd, Wuhan 430022, Peoples R China

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