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Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liao, B.[1] * ; Cao, P. -P.[1] * ; Zeng, M.[1] ; Zhen, Z.[1,2] ; Wang, H.[1] ; Zhang, Y. -N.[1,3] ; Hu, C. -Y.[1,4] ; Ma, J.[1] ; Li, Z. -Y.[1] ; Song, J.[1] ; Liu, J. -X.[1] ; Peng, L. -Y.[1] ; Liu, Y.[1] ; Ning, Q.[5] ; Liu, Z.[1,*1] ;
单位： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan [2]Department of Otolaryngology-Head and Neck Surgery, Peking University First Hospital, Beijing [3]Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin [4]Department of Ear, Nose and Throat, Xi’an Children’s Hospital, Xi’an [5]Department of Infectious Disease,Institute of Infectious Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
出处：
DOI： 10.1111/all.12667
ISSN：

关键词： cross-regulation interleukin 33 receptor thymic stromal lymphopoietin type 2 T-helper cell response

摘要：
BackgroundThymic stromal lymphopoietin (TSLP), IL-25, and IL-33 system contribute to the initiation and development of Th2 responses. This study aimed to explore the involvement of TSLP, IL-25, IL-33, and their receptors in type 2 T-helper (Th) responses in chronic rhinosinusitis with nasal polyps (CRSwNPs) and their cross-regulation in human nasal epithelial cells (HNECs). MethodsImmunohistochemistry, quantitative RT-PCR, ELISA, Bio-Plex assay, and flow cytometry were used to detect the expression of TSLP/common -like TSLP receptor (TSLPR)/IL-7 receptor (IL-7R), IL-25/IL-17B receptor (IL-17RB), and IL-33/membrane-bound ST2 (ST2L)/soluble ST2 (sST2) in sinonasal mucosa and HNECs. HNECs cultured at an air-liquid interface were used to explore the expression in regulation of these cytokine systems. ResultsCompared with controls and noneosinophilic CRSwNP, the expression of TSLP/TSLPR/IL-7R and ST2L/sST2 was significantly increased in eosinophilic CRSwNP, predominantly in epithelial cells. In contrast, the expression of IL-33 and IL-25/IL-17RB was enhanced in epithelial cells in both eosinophilic and noneosinophilic CRSwNP compared to controls. The expression of TSLP, TSLPR, and ST2L was positively correlated with symptom and computer tomography scan scores in eosinophilic CRSwNP and with Th2 cytokine expression in sinonasal mucosa. The expression of ST2L was correlated with TSLP and its receptor expression. TSLP could induce ST2L expression that promoted IL-33-induced TSLP expression in HNECs. In addition, TSLP/TSLPR/IL-7R and ST2L could be induced by Th2 cytokines, while IL-25/IL-17RB and IL-33 could be upregulated by Th1/Th17 cytokines, in HNECs. ConclusionsThe positive feedback loop between TSLP, IL-33 and their receptors, and Th2 cytokines may facilitate Th2-skewed inflammation in eosinophilic CRSwNP.

基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81020108018, 81325006, 81200733, 81300812]; Ministry of Health of China [201202005]; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT_14R20]; 12th five year science and technology support program [2014BAI07B04]

基金编号： 81020108018 81325006 81200733 81300812 201202005 IRT_14R20 2014BAI07B04

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 2 区 医学
小类 | 2 区 过敏 2 区 免疫学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 过敏 1 区 免疫学
JCR分区：
出版当年[2013]版：
Q1 IMMUNOLOGY Q1 ALLERGY
最新[2023]版：
Q1 ALLERGY Q1 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者单位： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan
共同第一作者：
通讯作者：
通讯机构： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan [*1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Otolaryngol Head & Neck Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China
推荐引用方式(GB/T 7714)：
Liao B.,Cao P. -P.,Zeng M.,et al.Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps[J].ALLERGY.2015,70(9):1169-1180.doi:10.1111/all.12667.
APA：
Liao, B.,Cao, P. -P.,Zeng, M.,Zhen, Z.,Wang, H....&Liu, Z..(2015).Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps.ALLERGY,70,(9)
MLA：
Liao, B.,et al."Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps".ALLERGY 70..9(2015):1169-1180

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