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YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels

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收录情况： ◇ SCIE

作者：

单位： [1]PLA Air Force, Dept Resp Med, Gen Hosp, Beijing 100142, Peoples R China [2]Hebei North Univ, Minist Educ, Zhangjiakou, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Resp Med, Wuhan 430074, Peoples R China [4]Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr Cardiol, Beijing, Peoples R China

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关键词： Hypoxia potassium channels pulmonary hypertension survivin YM155

摘要：

To test the hypothesis that chronic hypoxic pulmonary hypertension (CH-PH) is associated with increased survivin and decreased voltage-gated potassium (KV) channels expression in pulmonary arteries, rats were randomized as: normoxia (N); normoxia + YM155, survivin suppressor (NY); hypoxia (H); hypoxia + YM155 (HY). HY group had significantly reduced pulmonary arterial pressure, right ventricular weight and right ventricular hypertrophy compared with H group. Survivin mRNA and protein were detected in pulmonary arteries of rats with CH-PH, but not rats without CH-PH. YM155 downregulated survivin protein and mRNA. KV channel expression and activity were upregulated after YM155 treatment. Survivin may play a role in the pathogenesis of CH-PH.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区外周血管病 4 区药学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区外周血管病 4 区药学

JCR分区：

出版当年[2013]版：

Q3 PHARMACOLOGY & PHARMACY Q4 PERIPHERAL VASCULAR DISEASE

最新[2023]版：

Q3 PERIPHERAL VASCULAR DISEASE Q3 PHARMACOLOGY & PHARMACY

影响因子： 1.5 最新[2023版] 1.6 最新五年平均 1.456 出版当年[2013版] 1.362 出版当年五年平均 1.276 出版前一年[2012版] 1.234 出版后一年[2014版]

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第一作者单位： [1]PLA Air Force, Dept Resp Med, Gen Hosp, Beijing 100142, Peoples R China

通讯作者：

通讯机构： [1]PLA Air Force, Dept Resp Med, Gen Hosp, Beijing 100142, Peoples R China [*1]PLA Air Force, Dept Resp Med, Gen Hosp, 30 Fucheng Rd, Beijing 100142, Peoples R China

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