Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of China [81270507, 81272657]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430074, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
He Jiayi,Gong Jin,Ding Qiang,et al.Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats[J].FEBS LETTERS.2015,589(12):1359-1368.doi:10.1016/j.febslet.2015.04.010.
APA：
He, Jiayi,Gong, Jin,Ding, Qiang,Tan, Qinghai,Han, Ping...&Tian, Dean.(2015).Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats.FEBS LETTERS,589,(12)
MLA：
He, Jiayi,et al."Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats".FEBS LETTERS 589..12(2015):1359-1368
