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Embryonic liver fordin is involved in glucose glycolysis of hepatic stellate cell by regulating PI3K/Akt signaling

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China [2]Institute of Liver Diseases, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China [3]Department of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China [4]Institute of Liver Diseases, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China

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关键词： Liver fibrosis Embryonic liver fordin PI3K/Akt signaling Hepatic stellate cells Glucose glycolysis

摘要：

AIM To investigate the role of embryonic liver fordin (ELF) in liver fibrosis by regulating hepatic stellate cells (HSCs) glucose glycolysis. METHODS The expression of ELF and the glucose glycolysisrelated proteins were evaluated in activated HSCs. siRNA was used to silence ELF expression in activated HSCs in vitro and the subsequent changes in PI3K/Akt signaling and glucose glycolysis-related proteins were observed. RESULTS The expression of ELF increased remarkably in HSCs of the fibrosis mouse model and HSCs that were cultured for 3 wk in vitro. Glucose glycolysis-related proteins showed an obvious increase in the activated HSCs, such as phosphofructokinase, platelet and glucose transporter 1. ELF-siRNA, which perfectly silenced the expression of ELF in activated HSCs, led to the induction of glucose glycolysis-related proteins and extracellular matrix (ECM) components. Moreover, pAkt, which is an important downstream factor in PI3K/Akt signaling, showed a significant change in response to the ELF silencing. The expression of glucose glycolysis-related proteins and ECM components decreased remarkably when the PI3K/Akt signaling was blocked by Ly294002 in the activated HSCs. CONCLUSION ELF is involved in HSC glucose glycolysis by regulating PI3K/Akt signaling.

基金：

基金编号： 81300329 81401992

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中科院(CAS)分区：

出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区胃肠肝病学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区胃肠肝病学

JCR分区：

出版当年[2014]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 2.369 出版当年[2014版] 2.671 出版当年五年平均 2.433 出版前一年[2013版] 2.787 出版后一年[2015版]

第一作者：

第一作者单位： [1]Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China [2]Institute of Liver Diseases, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China

通讯作者：

通讯机构： [3]Department of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China

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Embryonic liver fordin is involved in glucose glycolysis of hepatic stellate cell by regulating PI3K/Akt signaling

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