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MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha

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收录情况： ◇ SCIE

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单位： [1]Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China

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关键词： miR-138 Alzheimer's disease Retinoic acid receptor alpha Tau Phosphorylation Glycogen synthase kinase-3 beta

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative dementia characterized by Ab deposition and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Emerging evidence shows that microRNAs (miRNAs) contribute to the pathogenesis of AD. Herein, we investigated the role of miR-138, a brain enriched miRNA, which is increased in AD patients. We found that miR-138 is increased in AD models, including N2a/APP and HEK293/tau cell lines. Overexpression of miR-138 activates glycogen synthase kinase-3 beta (GSK-3 beta), and increases tau phosphorylation in HEK293/tau cells. Furthermore, we confirm that retinoic acid receptor alpha (RARA) is a direct target of miR-138, and supplement of RARA substantially suppresses GSK-3 beta activity, and reduces tau phosphorylation induced by miR-138. In conclusion, our data suggest that miR-138 promotes tau phosphorylation by targeting the RARA/GSK-3b pathway. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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基金编号： 31371368

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出版当年[2014]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 3 区生物物理 4 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2013]版：

Q2 BIOPHYSICS Q2 CELL BIOLOGY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.8 最新五年平均 3.341 出版当年[2013版] 3.47 出版当年五年平均 3.582 出版前一年[2012版] 3.169 出版后一年[2014版]

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第一作者单位： [1]Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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