Matrix metalloproteinase-1 (MMP-1) has been implicated in several inflammatory and fibrotic diseases. We hypothesized that genetic variations in the MMP1 promoter region are associated with risk of radiation-induced lung injury (RILI). A cohort of 251 lung cancer patients was genotyped for five single nucleotide polymorphisms in the MMP1 promoter region. We found that rs1144393 AG/GG was strongly correlated with an increased occurrence of grade >= 2 RILI (p = 0.002). Additionally, patients with the rs1144393 AG/GG genotypes exhibited higher MMP-1 expression than patients with the AA genotype in lung tissues (n = 28, p = 0.022) and plasma samples (n = 40, p = 0.018). Our results indicated that rs1144393 in the MMP1 promoter region can be a predictor of grade >= 2 RILI in lung cancer patients treated with thoracic radiation.
基金：
National Nature Science Foundation of China [81272492, 81472921, 81372664]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Oncol,Wuhan,Hubei Province,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Bo,Yi Minxiao,Tang Yang,et al.MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy[J].ONCOTARGET.2016,7(43):70175-70184.doi:10.18632/oncotarget.12164.
APA：
Liu, Bo,Yi, Minxiao,Tang, Yang,Liu, Qingxu,Qiu, Hong...&Yuan, Xianglin.(2016).MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.ONCOTARGET,7,(43)
MLA：
Liu, Bo,et al."MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy".ONCOTARGET 7..43(2016):70175-70184
医学