Plasminogen activator inhibitor-1 (PAI-1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI-1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single-nucleotide polymorphisms in PAI-1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan-Meier analyses. Univariate and multivariate analyses revealed that PAI-1: rs7242 GT/GG was correlated with an increased occurrence of grade >= 3 RP (crude hazard ratio = 3.331; 95% confidence interval, 1.168-9.497; P = 0.024). Our results indicated that PAI-1: rs7242 in the 3'-untranslated region of PAI-1 can be a predictor of grade >= 3 RP before radiotherapy.
基金：
National Natural Science Foundation of China [81272492, 81472921]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, 1095,Jiefang Rd, Wuhan, Hunan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Bo,Tang Yang,Yi Minxiao,et al.Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients[J].CANCER MEDICINE.2017,6(3):681-688.doi:10.1002/cam4.1011.
APA：
Liu, Bo,Tang, Yang,Yi, Minxiao,Liu, Qingxu,Xiong, Huihua...&Yuan, Xianglin.(2017).Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients.CANCER MEDICINE,6,(3)
MLA：
Liu, Bo,et al."Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients".CANCER MEDICINE 6..3(2017):681-688
