Eighteen triterpenoids, abifarines A-R, including fourteen previously unknown and four artifacts, together with six known ones, were isolated from the branch and leaf of Abies fargesii. Their structures were elucidated by spectroscopic data analysis. The relative configurations of abifarines A and F were further confirmed by single-crystal X-ray diffraction analysis with Mo K alpha irradiation. All compounds were evaluated for their in vitro cytotoxicity against the mouse cancer B16 cell line, and human cancer HepG2 and MCF7 cell lines. (24R)-cycloartane-3 beta,24,25-triol and (24R)-cycloartane-3,beta,24,25,28-tetrol showed moderate anti-proliferative effect for B16 and HepG2 cell lines with IC50 values of 32.9, 19.5 mu M and 26.4, 21.5 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
基金：
Natural Science Foundation of China [31270394, 21572073]; Wuhan Program for Science and Technology [2013060501010158]; General Administration of Quality Supervision, Inspection and Quarantine of the PRC [2013IK156]
第一作者单位：[1]Huazhong Univ Sci & Technol, Fac Pharm, Tongji Med Coll, Hangkonglu 13, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Wenming,Chen Xu,Liu Ye,et al.Triterpenoids from the branch and leaf of Abies fargesii[J].PHYTOCHEMISTRY.2016,130:301-312.doi:10.1016/j.phytochem.2016.07.001.
APA：
Wu, Wenming,Chen, Xu,Liu, Ye,Wang, Yanmei,Tian, Tian...&Ruan, Hanli.(2016).Triterpenoids from the branch and leaf of Abies fargesii.PHYTOCHEMISTRY,130,
MLA：
Wu, Wenming,et al."Triterpenoids from the branch and leaf of Abies fargesii".PHYTOCHEMISTRY 130.(2016):301-312
