Two new azaphilone derivatives, chaephilones A (1) and B (2), were isolated from the fungus Chaetomium globosum, together with four structurally related analogs 3 - 6. The structures of 1 and 2 were elucidated by comprehensive spectroscopic analyses including HR-ESI-MS and NMR. The known compounds were identified as chaetomugilin Q (3), chaetomugilin D (4), 11-epichaetomugilin A (5), and chaetomugilin S (6) by comparing their NMR data and optical rotation values with those reported. Compound 2 represents the first example of azaphilone with an open furan ring. Compounds 1 and 2 were evaluated for cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by the MTS method.
基金：
National Natural Science Foundation of China [31370372, 31270395, 31200258]; New Century Excellent Talents in University; State Education Ministry of China [NCET-2008-0224]
第一作者单位：[1]Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Chunmei,Wang Jing,Zhu Hucheng,et al.Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum[J].CHEMISTRY & BIODIVERSITY.2016,13(4):422-426.doi:10.1002/cbdv.201500117.
APA：
Chen, Chunmei,Wang, Jing,Zhu, Hucheng,Wang, Jianping,Xue, Yongbo...&Zhang, Yonghui.(2016).Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum.CHEMISTRY & BIODIVERSITY,13,(4)
MLA：
Chen, Chunmei,et al."Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum".CHEMISTRY & BIODIVERSITY 13..4(2016):422-426
