Ten new cytochalasan alkaloids, termed armochaetoglobins A-J (1-10), and four known chaetoglobosins (11-14) were isolated from a methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated by a combination of spectroscopy, single-crystal X-ray crystallography, and ECD calculations. Armochaetoglobins A-E (1-5) represented the first examples of seco-chaetoglobosins arising from an oxidative cleavage of C-19 and C-20. Among these compounds, armochaetoglobin A (1) features an unusual pyrrole ring. The cytotoxic activities of 2-10 were evaluated, and armochaetoglobin H (8) showed moderate inhibitory activities against five human cancer cell lines, with ICso values ranging from 3.31 to 9.83 mu M.
基金：
Program for New Century Excellent Talents in University, State Education Ministry of China [2008-0224]; National Natural Science Foundation of China [31200258, 31370372, 31270395, 81202423]; National Science and Technology Project of China [2011ZX09102-004, 2013ZX09103001-020]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Chunmei,Wang Jianping,Liu Junjun,et al.Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare[J].JOURNAL OF NATURAL PRODUCTS.2015,78(6):1193-1201.doi:10.1021/np500626x.
APA：
Chen, Chunmei,Wang, Jianping,Liu, Junjun,Zhu, Hucheng,Sun, Bin...&Zhang, Yonghui.(2015).Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare.JOURNAL OF NATURAL PRODUCTS,78,(6)
MLA：
Chen, Chunmei,et al."Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare".JOURNAL OF NATURAL PRODUCTS 78..6(2015):1193-1201
