Metastasis of liver cancer is closely linked to tumor microenvironment, in which chemokines and their receptors act in an important role. The CXCR3, the receptor of chemokine CXCL9, belongs to a superfamily of rhodopsin-like seven transmembrane GPCRs and CXCR subfamily. In HCC tissues, CXCR3 was frequently upregulated and correlated with tumor size, tumor differentiation, portal invasion and metastasis. In the study, CXCR3-A isoform that was bound by CXCL9 was found to cause significant change of ERK1/2 phosphorylation level in the MAPK signaling pathway, consequently upregulating the MMP2 and MMP9 expression and promoting invasion and metastasis of CD133+ liver cancer cells. Also, CXCR3-A suppressed the adhesion ability of CD133+ liver cancer cells that stimulated by CXCL9 for 24h. These findings suggest that CXCR3 and its ligand CXCL9 could promote the metastasis of liver cancer cells and might be a potential target for the intervention of liver cancer metastasis.
基金：
National Natural Science Foundation of China [81272657, 81270507]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430074, Hubei Province, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Ding Qiang,Xia Yujia,Ding Shuping,et al.An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+liver cancer cells induced by CXCL9[J].ONCOTARGET.2016,7(12):14405-14414.doi:10.18632/oncotarget.7360.
APA：
Ding, Qiang,Xia, Yujia,Ding, Shuping,Lu, Panpan,Sun, Liang&Liu, Mei.(2016).An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+liver cancer cells induced by CXCL9.ONCOTARGET,7,(12)
MLA：
Ding, Qiang,et al."An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+liver cancer cells induced by CXCL9".ONCOTARGET 7..12(2016):14405-14414
医学