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Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Urol,Jiefang Ave 1095,Wuhan,Hubei,Peoples R China

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关键词： DLX6-AS1 Long non-coding RNA miR-26a PTEN Renal cell carcinoma RCC

摘要：

Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several types of cancer, including renal cell carcinoma (RCC). In this study, we identified an upregulated lncRNA, DLX6-AS1, in RCC tumor tissues compared with normal kidney tissues. Our data suggested that DLX6-AS1 promoted RCC cell growth and tumorigenesis via targeting miR-26a. In addition, we observed that PTEN overexpression restored the renal cancer cell growth and also rescued the RCC tumorigenesis. In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis.

基金：

基金编号： 81173608

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出版当年[2016]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学

JCR分区：

出版当年[2015]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 3.4 最新[2023版] 4.4 最新五年平均 3.952 出版当年[2015版] 4.24 出版当年五年平均 4.565 出版前一年[2014版] 3.53 出版后一年[2016版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Urol,Jiefang Ave 1095,Wuhan,Hubei,Peoples R China

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