Obesity is one of the most significant contributors to the development of type 2 diabetes mellitus. Tissue-specific glucocorticoids regulated by 11 beta-hydroxysteroid dehydrogenase enzyme (11 beta-HSD) type 1 are involved in central obesity and obesity-related comorbidities. Moderate downregulation of 11 beta-HSD1 can attenuate insulin insensitivity and the impairment of glucose-stimulated insulin secretion. Some of the beneficial effects of 11 beta-HSD1 inhibition may be mediated, at least in part, through inactivation of tissue-specific glucocorticoid action related to insulin signaling mechanisms, alleviation of abnormal cytokine profile and the improvement of beta-cell function. Thus, 11 beta-HSD1 is a promising target for the treatment and prevention of type 2 diabetes mellitus with obesity.
基金：
National Natural Science Foundation of China [81100581]; CIMF-Novo Nordisk China diabetes Yingcal Funding [2014SShao]; Fundamental Research Funds for the Central Universities [0118540208]
第一作者单位：[1]Three Gorges Univ, Peoples Hosp, Peoples Hosp Yichang 1, Div Endocrinol, Yichang, Peoples R China
通讯作者：
通讯机构：[4]Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Wuhan, Hubei, Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Tongji Med Coll, Jiefang Rd 1095, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Li Xia,Wang Jingli,Yang Qin,et al.11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus[J].AMERICAN JOURNAL OF THE MEDICAL SCIENCES.2017,354(4):408-414.doi:10.1016/j.amjms.2017.03.023.
APA：
Li, Xia,Wang, Jingli,Yang, Qin&Shao, Shiying.(2017).11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,354,(4)
MLA：
Li, Xia,et al."11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 354..4(2017):408-414
