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Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis

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收录情况： ◇ SCIE

作者：
R. Li[1,2] * ; K. Cui[1,2] ; T. Wang[1,2] ; S. Wang[1,2] ; X. Li[3] ; J. Qiu[3] ; G. Yu[3] ; J. Liu[1,2,*1] ; B. Wen[3,*2] ; K. Rao[1,2,*1] ;
单位： [1]Department of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [2]Institute of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [3]Department of Urology, The Affiliated Shenzhen Baoan Hospital of The South Medical University, Shenzhen, Guangdong, China
出处：
DOI： 10.1111/and.12693
ISSN：

关键词： apoptosis autophagy erectile dysfunction fibrosis hyperlipidemia

摘要：
Men with hyperlipidemia are more likely to have erectile dysfunction (ED) than those without hyperlipidemia, but the mechanisms are not fully understood. The aim of this study was to investigate the underlying mechanism of ED caused by hyperlipidemia. Fourteen 8-week-old Sprague-Dawley rats were randomly divided into two groups: a control group and a hyperlipidemia group (fed chow containing 4% cholesterol and 1% cholic acid). After 6 months, we assessed erectile function by performing cavernous nerve electrostimulation followed by intracavernosal pressure/mean arterial pressure measurements, as well as plasma lipid profile assessment in all rats. A transferase-mediated nick end labeling (TUNEL) assay, immunohistochemical staining and Western blotting were performed to determine the levels of apoptosis, autophagy and fibrosis in the penile tissue. Compared with the control group, the hyperlipidemia group exhibited: (i) increased plasma lipid levels; (ii) decreased erectile function; (iii) a decreased smooth muscle/collagen ratio; (iv) increased fibrosis; (v) increased apoptosis and decreased autophagy. Overall, hyperlipidemia may attenuate erectile function in rats by causing of cavernosal fibrosis.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81200435]; Science and technology plan project of Shenzhen [JCYJ20130329090921095]

基金编号： 81200435 JCYJ20130329090921095

语种：
外文
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中科院(CAS)分区：
出版当年[2016]版：
大类 | 4 区 医学
小类 | 4 区 男科学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 男科学
JCR分区：
出版当年[2015]版：
Q3 ANDROLOGY
最新[2023]版：
Q3 ANDROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者：
第一作者单位： [1]Department of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [2]Institute of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China
通讯作者：
通讯机构： [1]Department of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [2]Institute of Urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [3]Department of Urology, The Affiliated Shenzhen Baoan Hospital of The South Medical University, Shenzhen, Guangdong, China [*1]Department of Urology,Institute of urology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,Hubei,China [*2]Department of Urology, The Affiliated Shenzhen Baoan Hospital of The South Medical University, Shenzhen, Guangdong, China
推荐引用方式(GB/T 7714)：
R. Li,K. Cui,T. Wang,et al.Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis[J].ANDROLOGIA.2017,49(7):doi:10.1111/and.12693.
APA：
R. Li,K. Cui,T. Wang,S. Wang,X. Li...&K. Rao.(2017).Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis.ANDROLOGIA,49,(7)
MLA：
R. Li,et al."Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis".ANDROLOGIA 49..7(2017)

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