Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.
基金：
National Natural Science Foundation of China [81100581]; Bethune Merck Diabetes Research Fund [2018]; Cardiac rehabilitation and metabolic therapy research fund [2018]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Jiefang Rd 1095, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Mei,Chen Fuqiong,Wang Jingli,et al.Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients[J].CLINICAL IMMUNOLOGY.2018,197:77-85.doi:10.1016/j.clim.2018.09.005.
APA：
Wang, Mei,Chen, Fuqiong,Wang, Jingli,Zeng, Zhixuan,Yang, Qin&Shao, Shiying.(2018).Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients.CLINICAL IMMUNOLOGY,197,
MLA：
Wang, Mei,et al."Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients".CLINICAL IMMUNOLOGY 197.(2018):77-85
