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Blocking Interleukin-6 and Interleukin-8 Signaling Inhibits Cell Viability, Colony-forming Activity, and Cell Migration in Human Triple-negative Breast Cancer and Pancreatic Cancer Cells

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan, Hubei, Peoples R China [2]Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA

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关键词： Interleukin-6 interleukin-8 breast cancer pancreatic cancer bazedoxifene

摘要：

Background/Aim: Interleukin-6 (IL-6) and interleukin-8 (IL-8) play important roles in the progression of triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC). This is the first experiment to combine small molecules targeting these two signaling pathways to treat TNBC and PDAC cells. Materials and Methods: Cell viability, colony formation and cell migration assays were conducted when TNBC or PDAC cells were treated with bazedoxifene (targeting IL-6) or reparixin/SCH527123 (targeting IL-8) or their combination. Results: The combined treatment had a more potent inhibition of cell viability, colony formation and cell migration than monotherapy in TNBC and PDAC cells. The results also showed that the combination of bazedoxifene with SCH527123 seemed to be more effective than that with reparixin in inhibiting cell viability and colony formation of TNBC. Conclusion: Novel drug combinations of bazedoxifene and reparixin, as well as bazedoxifene and SCH527123 may provide more effective treatments for TNBC and PDAC.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2016]版：

Q3 ONCOLOGY

最新[2023]版：

Q4 ONCOLOGY

影响因子： 1.6 最新[2023版] 1.8 最新五年平均 1.937 出版当年[2016版] 1.925 出版当年五年平均 1.895 出版前一年[2015版] 1.865 出版后一年[2017版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan, Hubei, Peoples R China [2]Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA

通讯作者：

通讯机构： [2]Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA [*1]Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Dept Biochem & Mol Biol, 108 N Greene St, Baltimore, MD 21201 USA

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