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IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is related to triglyceride level in diet-induced obese rats

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单位： [1]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat, 157 Xiwu Rd, Xian 710061, Shaanxi, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China

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关键词： Childhood obesity High-fat diet IL-10 JAK-STAT Triglyceride

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Background: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia. Method: We evaluated IL-10 and signal transducer and activator of transcription 3 (STAT3) mRNA expression in adipose tissue (AT) as well as serum IL-10 in 62 children of 3 groups and in high-fat diet (HFD) induced obese rat. Expression of IL-10 and STAT3 protein in AT of diet-induced obese rats were examined over feed period. Results: Adipose IL-10 and STAT3 mRNA expression and serum IL-10 reduced in obese children with hypertriglyceridemia and in HFD obese rats. The protein expression of IL-10 and STAT3 decreased in AT of obese rats compared with the control rats at end time. Expression of IL-10 mRNA was negatively correlated to TG and LDL-C levels, and positively correlated to HDL-C, adiponectin and serum IL-10 levels. Conclusions: IL-10 expression and its downstream JAK-STAT pathway are down-regulated in obese children with hypertriglyceridemia and in HFD obese rats.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

JCR分区：

出版当年[2016]版：

Q3 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q3 ENDOCRINOLOGY & METABOLISM

影响因子： 2.8 最新[2023版] 3.1 最新五年平均 2.275 出版当年[2016版] 2.276 出版当年五年平均 1.739 出版前一年[2015版] 2.027 出版后一年[2017版]

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第一作者单位： [1]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat, 157 Xiwu Rd, Xian 710061, Shaanxi, Peoples R China

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