Serine proteinase inhibitor, clade E member 2 (SERPINE2), also known as protease nexin-1 (PN-1), is a member of the serpin family. Despite several reported roles of SERPINE2 in tumor development the histological distribution of SERPINE2 and its expression levels in a large variety of tumors remains unclear. Through expressed sequence tag database analysis, immunohistochemical staining of tissue microarrays and a literature review, it was revealed that SERPINE2 expression varied according to growth stages and tissue types. SERPINE2 is differentially expressed in a number of tumors and their normal tissue counterparts. SERPINE2 is identified most abundantly in adenocarcinomas. SERPINE2 serves diverse roles in a variety of tumors and therefore may serve as a promising biomarker for tumor diagnosis and prognosis.
基金：
National Natural Science Foundation of China [81101572, 81372326]; Tongji Hospital
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Haematol,1095 Jiefang Ave,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Haematol,1095 Jiefang Ave,Wuhan 430030,Hubei,Peoples R China[2]Imperial Coll London, Hammersmith Hosp, Dept Haematol, London W12 0HS, England
推荐引用方式(GB/T 7714)：
Yang Ying,Xin Xiangke,Fu Xing,et al.Expression pattern of human SERPINE2 in a variety of human tumors[J].ONCOLOGY LETTERS.2018,15(4):4523-4530.doi:10.3892/ol.2018.7819.
APA：
Yang, Ying,Xin, Xiangke,Fu, Xing&Xu, Danmei.(2018).Expression pattern of human SERPINE2 in a variety of human tumors.ONCOLOGY LETTERS,15,(4)
MLA：
Yang, Ying,et al."Expression pattern of human SERPINE2 in a variety of human tumors".ONCOLOGY LETTERS 15..4(2018):4523-4530
