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Lower long-term mortality in obese patients with community-acquired pneumonia: possible role of CRP

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单位: [1]Wuhan Peoples Hosp Dongxihu Dist, Xiehe Hosp Dongxihu Dist, Dept Crit Care Med, Wuhan 430000, Hubei, Peoples R China [2]Wanbei Coal Elect Grp Gen Hosp, Dept Resp, Suzhou 234011, Anhui, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430024, Hubei, Peoples R China [4]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Nephrol,Wuhan 430030,Hubei,Peoples R China [5]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Neurosurg,Wuhan 430030,Hubei,Peoples R China [6]Southern Theater Command, Gen Hosp, Neurol Specialized Hosp, Dept Neurol Rehabil, Guangzhou 510010, Guangdong, Peoples R China
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关键词: Obesity Community-Acquired Pneumonia Mortality C-reactive Protein

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OBJECTIVE: The present study aimed to investigate the relationship between obesity and mortality in patients with community-acquired pneumonia (CAP) in China. METHODS: In total, 909 patients with CAP were recruited for this study from January 2010 to June 2015. All patients were selected and divided into 4 groups according to their body mass index (BMI) values. All patients' clinical information was recorded. The associations among mortality; BMI; the 30-day, 6-month and 1-year survival rates for different BMI classes; the etiology of pneumonia in each BMI group; and the risk factors for 1-year mortality in CAP patients were analyzed. RESULT: With the exception of the level of C-reactive protein (CRP), no other clinical indexes showed significant differences among the different BMI groups. No significant differences were observed among all groups in terms of the 30-d and 6-month mortality rates (p > 0.05). There was a significantly lower risk of 1-year mortality in the obese group than in the nonobese group, (p < 0.05). Logistic regression analysis showed that there were seven independent risk factors for 1-year mortality in CAP patients, namely, age, cardiovascular disease, cerebrovascular disease, obesity, APACHE II score, level of CRP and CAP severity. CONCLUSION: Compared with nonobese patients with CAP, obese CAP patients may have a lower mortality rate, especially with regard to 1-year mortality, and CRP may be associated with the lower mortality rate in obese individuals than in nonobese individuals.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2017]版:
Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q2 MEDICINE, GENERAL & INTERNAL

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第一作者单位: [1]Wuhan Peoples Hosp Dongxihu Dist, Xiehe Hosp Dongxihu Dist, Dept Crit Care Med, Wuhan 430000, Hubei, Peoples R China
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