Mangiterpenes A-C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Mangiterpenes A-C and 2',3'-seco-manginoid C, four undescribed sesquiterpene/monoterpene-shikimate-conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A-C represent the first examples of sesquiterpene-shikimate-conjugated spirocyclic meroterpenoids, and 2',3'-seco-manginoid C features an unexpected 2',3'-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 mu M. It showed an anti-inflammatory effect by means of blocking in the NF-kappa B signaling pathway and decreasing the expression of inflammatory mediators.
基金：
Program for Changjiang Scholars of the Ministry of Education of the People's Republic of China [T2016088]; National Natural Science Foundation for Distinguished Young Scholars [81725021]; National Science and Technology Project of China [2018ZX09201001-001-003]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Keliang,Chen Chunmei,Guo Jieru,et al.Mangiterpenes A-C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae[J].PHYTOCHEMISTRY.2019,164:236-242.doi:10.1016/j.phytochem.2019.05.018.
APA：
Chen, Keliang,Chen, Chunmei,Guo, Jieru,Sun, Weiguang,Liu, Junjun...&Zhang, Yonghui.(2019).Mangiterpenes A-C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.PHYTOCHEMISTRY,164,
MLA：
Chen, Keliang,et al."Mangiterpenes A-C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae".PHYTOCHEMISTRY 164.(2019):236-242
