Manginoids A-G (1-7), seven monoterpene-shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1-4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5 '-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.0(3,7)]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11 beta-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 mu M.
基金：
Ministry of Education of the People's Republic of China [T2016088]; National Science Fund for Distinguished Young Scholars [8172500151]; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST); Innovative Research Groups of the National Natural Science Foundation of China [81721005]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Keliang,Zhang Xuwen,Sun Weiguang,et al.Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae[J].ORGANIC LETTERS.2017,19(21):5956-5959.doi:10.1021/acs.orglett.7b02955.
APA：
Chen, Keliang,Zhang, Xuwen,Sun, Weiguang,Liu, Junjun,Yang, Jing...&Zhang, Yonghui.(2017).Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae.ORGANIC LETTERS,19,(21)
MLA：
Chen, Keliang,et al."Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae".ORGANIC LETTERS 19..21(2017):5956-5959
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