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Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wei, Xiao[1] * ; Wei, Rui[1] ; Jiang, Guiying[1] ; Jia, Yijuan[2] ; Lou, Hua[1] ; Yang, Zongyuan[1] ; Luo, Danfeng[1] ; Huang, Quanfu[3] ; Xu, Sen[1] ; Yang, Xin[1] ; Zhou, Ying[1] ; Li, Xiaoting[1] ; Ji, Teng[1] ; Hu, Junbo[4] ; Xi, Ling[1] ; Ma, Ding[1] ; Ye, Fei[5] ; Gao, Qinglei[1] ;
单位： [1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Obstet & Gynecol,Wuhan,Hubei,Peoples R China [2]Wuhan First Hosp, Dept Obstet & Gynecol, Wuhan 430022, Hubei, Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Thorac Surg,Wuhan,Hubei,Peoples R China [4]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Canc Biol Res Ctr,Key Lab,Minist Educ,Wuhan,Hubei,Peoples R China [5]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Neurosurg,Wuhan,Hubei,Peoples R China
出处：
DOI： 10.2217/nnm-2018-0334
ISSN：

关键词： cancer cellular uptake endocytic pathways matrix stiffness nanoparticle

摘要：
To investigate the influence of tissue mechanics on the cellular uptake efficiency of nanoparticles (NPs) in cancer. Materials & methods: Collagen-coated polyacrylamide gels were prepared as model substrates. Coumarin 6-loaded poly(lactic-co-glycolic) acid micelles (C6-NPs) were prepared to investigate the cellular uptake of NPs. Results: We demonstrated that substrate stiffness modulated the cellular uptake of NPs of cancer. Mechanistically, mechanical cues exerted influence on the clathrin-mediated endocytosis and caveolae-mediated endocytosis pathways, which mediated stiffness-regulated cellular uptake of NPs. Conclusion: Our findings shed light on the regulatory role of the mechanical cues on the cellular uptake of NPs and will facilitate the selection of clinical patients who might benefit from a given nanotherapy. [GRAPHICS]

基金：
'973' Program of China [2015CB553903]; National Science-technology Supporting Plan Projects [2015BAI13B05]; National Science and Technology Major Sub-Project [2018ZX10301402-002]; Technical Innovation Special Project of Hubei Province [2018ACA138]; National Key Research & Development Program of China [2016YFC0902901]; National Science Foundation of China [81472783, 81630060, 81230038, 81372801, 81572570, 81772787, 81472444, 81402159, 81602284, 81202061, 81272426]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 2 区 生物工程与应用微生物 3 区 纳米科技
最新[2025]版：
大类 | 4 区 医学
小类 | 3 区 生物工程与应用微生物 4 区 纳米科技
JCR分区：
出版当年[2017]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Obstet & Gynecol,Wuhan,Hubei,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Xiao,Wei Rui,Jiang Guiying,et al.Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways[J].NANOMEDICINE.2019,14(5):613-626.doi:10.2217/nnm-2018-0334.
APA：
Wei, Xiao,Wei, Rui,Jiang, Guiying,Jia, Yijuan,Lou, Hua...&Gao, Qinglei.(2019).Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways.NANOMEDICINE,14,(5)
MLA：
Wei, Xiao,et al."Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways".NANOMEDICINE 14..5(2019):613-626

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