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Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

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收录情况： ◇ SCIE

作者：
Jiang, Rui[1] * ; Jiang, Yaping[2] ; Xia, Ping[1] ; Luo, Guangwei[3] ; Huang, Wei[1] ; Hu, Zhimin[1] ; Cheng, Guilian[1] ; Xiong, Yin[1] ; Wang, Yueqin[1] ; Cui, Tianpen[1,*1] ;
单位： [1]HUST, Tongji Med Coll, Wuhan Hosp 1, Lab Clin Immunol, Wuhan, Hubei, Peoples R China [2]HUST, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Hubei, Peoples R China [3]HUST, Tongji Med Coll, Wuhan Hosp 1, Dept Resp Med, Wuhan, Hubei, Peoples R China
出处：
DOI： 10.1159/000494505
ISSN：

关键词： Cigarette smoke TIM4 Dendritic cells Th2 polarization

摘要：
Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Stimulated by CSE, immature DCs from murine bone marrow showed upregulated levels of TIM4. Cocultured with CD4+ T cells, stimulated DCs increased the ratio of IL-4+ versus IFN-gamma+ of CD4+ T cells. This suggests a differentiation towards Th2 response. Moreover, antibodies against TIM4 reversed the upexpression of the IL-4+/IFN-gamma+ ratio provoked by CSE, indicating that the Th2 polarization which was induced by CSE is via TIM4 mechanisms. CSE could activate mitogen-activated protein kinase pathways like ERK and p38. Upregulation of TIM4 expression by CSE stimulation was found to be inhibited by an ERK inhibitor but not p38 and JNK. In conclusion, DC-induced Th2 polarization is a hallmark of CSE allergy, and this aspect can be explained by CSE-induced TIM4 expression. (C) 2018 S. Karger AG, Basel

基金：
National Nature Science Foundation of China [81170038]; Wuhan Health and Family Planning Committee Research Project [WX17A01]
语种：
外文
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中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 4 区 过敏 4 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 免疫学
JCR分区：
出版当年[2017]版：
Q3 ALLERGY Q3 IMMUNOLOGY
最新[2023]版：
Q3 ALLERGY Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者单位： [1]HUST, Tongji Med Coll, Wuhan Hosp 1, Lab Clin Immunol, Wuhan, Hubei, Peoples R China
通讯作者：
通讯机构： [1]HUST, Tongji Med Coll, Wuhan Hosp 1, Lab Clin Immunol, Wuhan, Hubei, Peoples R China [*1]HUST, Lab Clin Immunol, Wuhan Hosp 1, 215 Zhongshan Dadao, Wuhan 430022, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Jiang Rui,Jiang Yaping,Xia Ping,et al.Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways[J].INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY.2019,178(3):219-228.doi:10.1159/000494505.
APA：
Jiang, Rui,Jiang, Yaping,Xia, Ping,Luo, Guangwei,Huang, Wei...&Cui, Tianpen.(2019).Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways.INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY,178,(3)
MLA：
Jiang, Rui,et al."Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways".INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 178..3(2019):219-228

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