Since the blood vessel epicardial substance or Popeye domain-containing protein 1 (BVES/POPDC1) was first identified in the developing heart by two independent laboratories in 1999, an increasing number of studies have investigated the structure, function, and related diseases of BVES/POPDC1. During the first 10 years following the discovery of BVES/POPDC1, studies focused mainly on its structure, expression patterns, and functions. Based on these studies, further investigations conducted over the previous decade examined the role of BVES/POPDC1 in human diseases, such as colitis, heart diseases, and human cancers. This review provides an overview of the structure and expression of BVES/POPDC1, mainly focusing on its potential role and mechanism through which it is involved in human cancers.
基金：
National Natural Science Foundation of China [81472311, 81572419, 81702396]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Han Ping,Lei Yu,Li Dongxiao,et al.Ten years of research on the role of BVES/POPDC1 in human disease: a review[J].ONCOTARGETS AND THERAPY.2019,12:1279-1291.doi:10.2147/OTT.S192364.
APA：
Han, Ping,Lei, Yu,Li, Dongxiao,Liu, Jingmei,Yan, Wei&Tian, Dean.(2019).Ten years of research on the role of BVES/POPDC1 in human disease: a review.ONCOTARGETS AND THERAPY,12,
MLA：
Han, Ping,et al."Ten years of research on the role of BVES/POPDC1 in human disease: a review".ONCOTARGETS AND THERAPY 12.(2019):1279-1291
