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Infections Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China

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收录情况： ◇ SCIE

作者：
Lan Zhu [a,b] * ; Nianqiao Gong[a,b] * ; Bin Liu[a,b] ; Xia Lu [a,b] ; Dong Chen [a,b] ; Song Chen [a,b] ; Hongge Shu [c] ; Ke Ma [d] ; Xizhen Xu [e] ; Zhiliang Guo [a] ; Enfeng Lu [f] ; Dongrui Chen [g] ; Qinggang Ge [h] ; Junchao Cai [i] ; Jipin Jiang [a,b] ; Lai Wei [a,b] ; Weijie Zhang [a,b] ; Gang Chen [a,b,*1] ; Zhishui Chen [a,b,*1] ;
单位： [a]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China [c]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [d]Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [e]Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [f]Department of Nephrology, 923 Hospital of PLA, Nanning, China [g]Department of Nephrology, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University, Nanjing, China [h]Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China [i]Suzhou Caibo Medical Research Institute, Suzhou, China
出处：
DOI： 10.1016/j.eururo.2020.03.039
ISSN：

关键词： Kidney transplantation Coronavirus disease 2019 Immunosuppression Pneumonia Outcome

摘要：
Background: Previous studies on coronavirus disease 2019 (COVID-19) have focused on populations with normal immunity, but lack data on immunocompromised populations. Objective: To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. Design, setting, and participants: A total of 10 renal transplant recipients with laboratory-confirmed COVID- 19 pneumonia were enrolled in this retrospective study. In addition, 10 of their family members diagnosed with COVID-19 pneumonia were included in the control group. Intervention: Immunosuppressant reduction and low-dose methylprednisolone therapy. Outcome measurements and statistical analysis: The clinical outcomes (the severity of pneumonia, recovery rate, time of virus shedding, and length of illness) were compared with the control group by statistical analysis. Results and limitations: The clinical symptomatic, laboratory, and radiological characteristics of COVID-19 pneumonia in the renal transplant recipients were similar to those of severe COVID-19 pneumonia in the general population. The severity of COVID-19 pneumonia was greater in the transplant recipients than in the control group (five severe/three critical cases vs one severe case). Five patients developed transient renal allograft damage. After a longer time of virus shedding (28.4 9.3 vs 12.2 4.6 d in the control group) and a longer course of illness (35.3 8.3 vs 18.8 10.5 d in the control group), nine of the 10 transplant patients recovered successfully after treatment. One patient developed acute renal graft failure and died of progressive respiratory failure. Conclusions: Kidney transplant recipients had more severe COVID-19 pneumonia than the general population, but most of them recovered after a prolonged clinical course and virus shedding. Findings from this small group of cases may have important implications for the treatment of COVID-19 pneumonia in immunosuppressed populations. Patient summary: Immunosuppressed transplant recipients with coronavirus disease 2019 infection had more severe pneumonia, but most of them still achieved a good prognosis after appropriate treatment. ©

基金：
The study was supported by Hubei Science and Technology Plan, China (grant number 2017ACA096).
语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 泌尿学与肾脏学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 泌尿学与肾脏学
JCR分区：
出版当年[2018]版：
Q1 UROLOGY & NEPHROLOGY
最新[2023]版：
Q1 UROLOGY & NEPHROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者单位： [a]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China
共同第一作者：
通讯作者：
通讯机构： [a]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China [*1]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
推荐引用方式(GB/T 7714)：
Lan Zhu,Nianqiao Gong,Bin Liu,et al.Infections Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China[J].EUROPEAN UROLOGY.2020,77(6):748-754.doi:10.1016/j.eururo.2020.03.039.
APA：
Lan Zhu,Nianqiao Gong,Bin Liu,Xia Lu,Dong Chen...&Zhishui Chen.(2020).Infections Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China.EUROPEAN UROLOGY,77,(6)
MLA：
Lan Zhu,et al."Infections Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China".EUROPEAN UROLOGY 77..6(2020):748-754

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