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Diagnostic power of scleral spur length in primary open-angle glaucoma

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单位： [1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430022, Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Ophthalmol,Wuhan 430030,Peoples R China

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关键词： Scleral spur length Schlemm's canal Primary open-angle glaucoma Swept-source optical coherence tomography Receiver operating characteristic curve

摘要：

Purpose To investigate the diagnostic capability of scleral spur length in discriminating eyes with primary open-angle glaucoma (POAG) from healthy eyes. Methods Seventy-eight eyes of 78 patients with POAG and 93 eyes of 93 age-, sex- and axial length-matched healthy subjects were included. The scleral spur length was measured using swept-source optical coherence tomography. Receiver operating characteristic (ROC) curves were derived based on the measurements. Results The scleral spur length was significantly shorter in POAG eyes compared with healthy eyes (Method I, 164.91 +/- 23.36 vs. 197.60 +/- 25.32 mu m; Method II, 145.15 +/- 16.59 vs. 166.95 +/- 19.31 mu m; Method III, 162.33 +/- 22.83 vs. 185.12 +/- 23.58 mu m, respectively; all p < 0.001). The areas under ROC curves were 0.841 (Method I), 0.810 (Method II), and 0.753 (Method III) for the scleral spur length. Moreover, Schlemm's canal area was significantly associated with the scleral spur length (Method I) in both POAG (beta = 0.027; p < 0.001) and healthy (beta = 0.016; p = 0.009) groups. Conclusions The scleral spur length had a good discriminating capability between POAG and healthy eyes, and it could be a novel biomarker for POAG evaluation clinically.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 3 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区眼科学

JCR分区：

出版当年[2018]版：

Q2 OPHTHALMOLOGY

最新[2023]版：

Q2 OPHTHALMOLOGY

影响因子： 2.4 最新[2023版] 2.7 最新五年平均 2.25 出版当年[2018版] 2.209 出版当年五年平均 2.249 出版前一年[2017版] 2.396 出版后一年[2019版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430022, Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Ophthalmol,Wuhan 430030,Peoples R China

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